Počet záznamů: 1
The role of nitric oxide during embryonic wound healing
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SYSNO ASEP 0517499 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of nitric oxide during embryonic wound healing Tvůrce(i) Abaffy, Pavel (BTO-N)
Tománková, Silvie (BTO-N) RID
Naraine, Ravindra (BTO-N)
Kubista, Mikael (BTO-N) RID
Šindelka, Radek (BTO-N) RIDCelkový počet autorů 5 Číslo článku 815 Zdroj.dok. BMC Genomics. - : BioMed Central - ISSN 1471-2164
Roč. 20, č. 1 (2019)Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Xenopus laevis ; Nitric oxide ; Wound healing ; Transcriptome Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA17-24441S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000496463200005 DOI 10.1186/s12864-019-6147-6 Anotace Background The study of the mechanisms controlling wound healing is an attractive area within the field of biology, with it having a potentially significant impact on the health sector given the current medical burden associated with healing in the elderly population. Healing is a complex process and includes many steps that are regulated by coding and noncoding RNAs, proteins and other molecules. Nitric oxide (NO) is one of these small molecule regulators and its function has already been associated with inflammation and angiogenesis during adult healing. Results Our results showed that NO is also an essential component during embryonic scarless healing and acts via a previously unknown mechanism. NO is mainly produced during the early phase of healing and it is crucial for the expression of genes associated with healing. However, we also observed a late phase of healing, which occurs for several hours after wound closure and takes place under the epidermis and includes tissue remodelling that is dependent on NO. We also found that the NO is associated with multiple cellular metabolic pathways, in particularly the glucose metabolism pathway. This is particular noteworthy as the use of NO donors have already been found to be beneficial for the treatment of chronic healing defects (including those associated with diabetes) and it is possible that its mechanism of action follows those observed during embryonic wound healing. Conclusions Our study describes a new role of NO during healing, which may potentially translate to improved therapeutic treatments, especially for individual suffering with problematic healing. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2020 Elektronická adresa https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-019-6147-6
Počet záznamů: 1