Počet záznamů: 1
Diurnal expression of ABC and SLC transporters in jejunum is modulated by adrenalectomy
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SYSNO ASEP 0511931 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Diurnal expression of ABC and SLC transporters in jejunum is modulated by adrenalectomy Tvůrce(i) Vagnerová, Karla (FGU-C) RID, ORCID
Ergang, Peter (FGU-C) RID, ORCID
Soták, Matúš (FGU-C) RID, ORCID, SAI
Balounová, Kateřina (FGU-C) RID, ORCID
Kvapilová, Pavlína (FGU-C)
Vodička, Martin (FGU-C) RID, ORCID, SAI
Pácha, Jiří (FGU-C) RID, ORCIDČíslo článku 108607 Zdroj.dok. Comparative Biochemistry and Physiology Part C. - : Elsevier - ISSN 1532-0456
Roč. 226, Dec (2019)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adrenalectomy ; circadian rhythms ; corticosterone ; solute carriers ; ATP-binding cassette transporters Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA13-08304S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000496603700003 EID SCOPUS 85070900880 DOI 10.1016/j.cbpc.2019.108607 Anotace The circadian clock system drives many physiological processes, including plasma concentration of glucocorticoids and epithelial transport of some ions and nutrients. As glucocorticoids entrain the circadian rhythms in various peripheral organs, we examined whether adrenalectomy affects the expression and circadian rhythmicity of intestinal transporters of the solute carrier (SLC) and ATP-binding cassette (ABC) families, which participate in intestinal barriers for absorption of nutrients, nonnutrients and oral drugs. The rat jejunum showed rhythmic circadian profiles of Sglt1, Pept1, Nhe3, Mdr1 and Mrp2 but not Mct1, Oct1, Octn1, Oatp1, Cnt1 and Bcrp. With the exception of Pept1 and Mct1, adrenalectomy decreased the expression of all rhythmic and arrhythmic transporters including the amplitude of Sglt1 and Nhe3 rhythms but minimally affected the phases of rhythmic transporters except of Nhe3. Similarly, adrenalectomy downregulated the expression of rhythmic (Pparα, Hlf, Pgc1α) and arrhythmic (Hnf1β, Hnf4α) transcription factors, which are known to regulate the expression of transporters. We conclude that endogenous corticosteroids have a profound effect on the expression of intestinal SLC and ABC transporters and their nuclear transcription factors. The circulating corticosteroids are necessary for maintaining upregulated expression of Sglt1, Oct1, Octn1, Oatp1, Cnt1, Nhe3, Mdr1, Bcrp, Mrp2, Pparα, Pgc1α, Hnf1β, Hnf4α and Hlf and for maintaining the high amplitude of Sglt1, Nhe3, Pparα, Pgc1α and Hlf circadian rhythms. The study demonstrates that signals from the adrenal gland are necessary for maintaining the expression of arrhythmic and rhythmic intestinal transporters and that changes in the secretion of corticosteroids associated with stress might reorganize intestinal transport barriers. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2020 Elektronická adresa https://doi.org/10.1016/j.cbpc.2019.108607
Počet záznamů: 1