Počet záznamů: 1
Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer
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SYSNO ASEP 0493577 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer Tvůrce(i) Huhn, S. (DE)
da Silva Filho, M.I. (DE)
Sanmuganantham, T. (DE)
Pichulik, T. (DE)
Catalano, C. (DE)
Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Vymetálková, Veronika (UEM-P) RID
Jirásková, Kateřina (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Vodička, Pavel (UEM-P) RID
Löffler, M.W. (DE)
Courth, L. (DE)
Wehkamp, J. (DE)
Din, F.V.N. (DE)
Timofeeva, M. (GB)
Farrington, S.M. (GB)
Jansen, L. (DE)
Hemminki, K. (DE)
Chang-Claude, J. (DE)
Brenner, H. (DE)
Hoffmeister, M. (DE)
Dunlop, G.D. (GB)
Weber, R. (DE)
Foersti, A. (DE)Číslo článku e0199350 Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 13, č. 6 (2018)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova sequence ; genes ; susceptibility ; recognition Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Gastroenterology and hepatology CEP LD14050 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy NV15-26535A GA MZd - Ministerstvo zdravotnictví NV15-27580A GA MZd - Ministerstvo zdravotnictví Institucionální podpora UEM-P - RVO:68378041 UT WOS 000435802500076 EID SCOPUS 85048861525 DOI 10.1371/journal.pone.0199350 Anotace Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort of sporadic colorectal cancer (CRC) (1237 cases, 787 controls) for their association with CRC risk and survival. Five SNPs were found to be associated with CRC risk and eight with survival at 5% significance level. In a replication analysis using data of two large genome-wide association studies (GWASs) from Germany (DACHS: 1798 cases and 1810 controls) and Scotland (2210 cases and 9350 controls) the associations found in the Czech discovery set were not confirmed. However, expression analysis in human gut-related tissues and immune cells revealed that the NLRs associated with CRC risk or survival in the discovery set were expressed in primary human colon or rectum cells, CRC tissue and/or cell lines, providing preliminary evidence for a potential involvement of NLRs in general in CRC development and/or progression. Most interesting was the finding that the enigmatic development-related NLRP5 (also known as MATER) was not expressed in normal colon tissue but in colon cancer tissue and cell lines. Future studies may show whether regulatory variants instead of coding variants might affect the expression of NLRs and contribute to CRC risk and survival. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2019
Počet záznamů: 1