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Relative position of the atrioventricular canal determines the electrical activation of developing reptile ventricles
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SYSNO ASEP 0493024 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Relative position of the atrioventricular canal determines the electrical activation of developing reptile ventricles Tvůrce(i) Gregorovičová, Martina (FGU-C) RID, ORCID, SAI
Sedmera, David (FGU-C) RID, ORCID, SAI
Jensen, B. (NL)Číslo článku jeb178400 Zdroj.dok. Journal of Experimental Biology. - : Company of Biologists - ISSN 0022-0949
Roč. 221, č. 11 (2018)Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova development ; cardiac conduction system ; heart ; optical mapping Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA16-02972S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000438916100019 EID SCOPUS 85048312946 DOI 10.1242/jeb.178400 Anotace Squamate reptiles appear to lack the specialized His-Purkinje system that enables the cardiac ventricle to be activated from apex to base as in mammals and birds. Instead, activation may simply spread from where the atrioventricular canal connects to the base. Gja5, which encodes Cx40, which allows fast impulse propagation, was expressed throughout the ventricles of developing anole lizards. Activation was optically recorded in developing corn snake and central bearded dragon. Early embryonic ventricles were broad in shape, and activation propagated from the base to the right. Elongated ventricles of later stages were activated from base to apex. Before hatching of the snake, the ventricle developed a cranial extension on the left and activation propagated from the base to the caudal apex and the cranial extension. In squamate reptiles, the pattern of electrical activation of the cardiac ventricle is dependent on the position of the atrioventricular canal and the shape of the ventricle. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
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