Počet záznamů: 1
Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol
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SYSNO ASEP 0451351 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol Tvůrce(i) Topinka, Jan (UEM-P) RID, ORCID
Rössner ml., Pavel (UEM-P) RID, ORCID
Milcová, Alena (UEM-P)
Schmuczerová, Jana (UEM-P) RID
Pěnčíková, K. (CZ)
Rössnerová, Andrea (UEM-P) RID
Ambrož, Antonín (UEM-P)
Štolcpartová, Jitka (UEM-P)
Bendl, J. (CZ)
Hovorka, J. (CZ)
Machala, M. (CZ)Celkový počet autorů 11 Zdroj.dok. Environmental Pollution. - : Elsevier - ISSN 0269-7491
Roč. 202, jul (2015), s. 135-145Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova air pollution ; carcinogenic PAH ; dioxin-like activity ; DNA adducts ; oxidative damage ; particulate matter Vědní obor RIV DN - Vliv životního prostředí na zdraví CEP GBP503/12/G147 GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000354581900017 EID SCOPUS 84925844096 DOI 10.1016/j.envpol.2015.03.024 Anotace This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (d(ae), mu m) coarse (1 < d(ae) < 10), upper- (0.5 < d(ae) < 1) and lower-accumulation (0.17 < d(ae) < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 study days and contained 44% of total c-PAHs, while the ultrafine fraction contained only 11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative DNA damage is not induced by EOM. (C) 2015 Elsevier Ltd. All rights reserved. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2016
Počet záznamů: 1