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Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples
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SYSNO ASEP 0340932 Druh ASEP A - Abstrakt Zařazení RIV Není vybrán druh dokumentu Název Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples Tvůrce(i) Spížek, Jaroslav (MBU-M)
Novotná, Jitka (MBU-M)
Olšovská, Jana (MBU-M)
Smutná, Yvona (MBU-M)
Kadlčík, Stanislav (MBU-M) RID, ORCID
Koběrská, Markéta (MBU-M) ORCID
Ulanová, Dana (MBU-M)
Najmanová, Lucie (MBU-M) RID
Janata, Jiří (MBU-M) RID, ORCIDZdroj.dok. Annual World Congress of Industrial Biotechnology 2009 /2./. - Seoul : COEX Convention and Exhibition Center, 2009
S. 71-71Poč.str. 1 s. Akce Annual World Congress of Industrial Biotechnology 2009 /2./ Datum konání 05.04.2009-07.04.2009 Místo konání Seoul Země KR - Korejská republika Typ akce WRD Jazyk dok. eng - angličtina Země vyd. KR - Korejská republika Klíč. slova lincomycin Vědní obor RIV EE - Mikrobiologie, virologie CEP IAA500200810 GA AV ČR - Akademie věd CEZ AV0Z50200510 - MBU-M (2005-2011) Anotace Lincomycin and its derivatives are potent antibiotics used in human and veterinary medicine. Lincomycin molecule is composed of two subunits, methylthiolincosamide (MTL) and methylproline linked by an amide bond. The gene cluster of Streptomyces lincolnensis controlling lincomycin biosynthesis contains 29 ORFs with putative biosynthetic/regulatory (lmb) and resistance (lmr) functions. Six ORFs (lmbA, B1, B2, W, X, Y) were found to have their counterparts among genes controlling biosynthesis of anthramycin sharing with lincomycin the initial reactions of biosynthesis of proline derivatives. Functions of LmbB1 and LmbB2 proteins were demonstrated in vitro; by gene inactivation analysis lmbA, X, W genes were confirmed to be included in propylproline biosynthesis Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2010
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