Počet záznamů: 1
Organization of Carotenoid Aggregates in Membranes Studied Selectively using Resonance Raman Optical Activity
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SYSNO ASEP 0583160 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Organization of Carotenoid Aggregates in Membranes Studied Selectively using Resonance Raman Optical Activity Tvůrce(i) Hachlica, N. (PL)
Stefanska, M. (CH)
Mach, M. (PL)
Kowalska, M. (PL)
Wydro, P. (PL)
Domagala, A. (PL)
Kessler, Jiří (UOCHB-X) RID, ORCID
Zajac, G. (PL)
Kaczor, A. (PL)Zdroj.dok. Small. - : Wiley - ISSN 1613-6810
(2024)Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova aggregates ; carotenoids ; chirality ; membranes ; raman optical octivity ; supramolecules Způsob publikování Open access Institucionální podpora UOCHB-X - RVO:61388963 DOI 10.1002/smll.202306707 Anotace In living organisms, carotenoids are incorporated in biomembranes, remarkably modulating their mechanical characteristics, fluidity, and permeability. Significant resonance enhancement of Raman optical activity (ROA) signals of carotenoid chiral aggregates makes resonance ROA (RROA), a highly selective tool to study exclusively carotenoid assemblies in model membranes. Hence, RROA is combined with electronic circular dichroism (ECD), dynamic light scattering (DLS), molecular dynamics, and quantum-chemical calculations to shed new light on the carotenoid aggregation in dipalmitoylphosphatidylcholine (DPPC) liposomes. Using representative members of the carotenoid family: apolar alpha-carotene and more polar fucoxanthin and zeaxanthin, the authors demonstrate that the stability of carotenoid aggregates is directly linked with their orientation in membranes and the monomer structures inside the assemblies. In particular, polyene chain distortion of alpha-carotene molecules is an important feature of J-aggregates that show increased orientational freedom and stability inside liposomes compared to H-assemblies of more polar xanthophylls. In light of these results, RROA emerges as a new tool to study active compounds and drugs embedded in membranes. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2025 Elektronická adresa https://doi.org/10.1002/smll.202306707
Počet záznamů: 1