0565156 - ÚCHP 2023 CZ eng A - Abstrakt
Hamala, Vojtěch - Červenková Šťastná, Lucie - Karban, Jindřich
Hybrid Organometallic Galectin Inhibitors.
Book of Abstracts. 2022, č. článku P147B..
[International Conference on Organometallic Chemistry /29./. 17.07.2022-22.07.2022, Prague]
Institucionální podpora: RVO:67985858
Klíčová slova: galectin inhibitors * glycomimetcs * organometallic compounds * carbohydrates
Obor OECD: Medicinal chemistry

In this project, we replace the aromatic substituent with arene-containing organometallic structures – ferrocenes1and ruthenium arenes2 with known antitumor or antimetastatic properties. This creates a hybrid molecule that can act as both a galectin inhibitor and a cytotoxic and/or antimetastatic agent. We have confirmed that both ferrocenes and ruthenium arenes moieties are viable bioisosteric replacement for planar arenes in the context of glycomimetic galectin inhibitors. Prepared organometallic inhibitors have a comparable or even better binding affinity to galectins than their nonmetallic counterparts.

Trvalý link: https://hdl.handle.net/11104/0336663