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Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin
- 1.0561943 - ÚACH 2023 RIV CH eng J - Článek v odborném periodiku
Sredojević, D. - Lazić, V. - Pirković, I. - Perisa, J. - Murafa, Nataliya - Spremo-Potparevic, B. - Zivkovic, L. - Topalović, D. - Zarubica, A. - Krivokuća, M. J. - Nedeljković, J. M.
Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin.
Nanomaterials. Roč. 12, č. 18 (2022), č. článku 3195. E-ISSN 2079-4991
Grant CEP: GA MŠMT(CZ) LM2018124
Institucionální podpora: RVO:61388980
Klíčová slova: zirconium dioxide nanoparticles * dihydroquercetin * silver nanoparticles * toxicity * antimicrobial ability
Obor OECD: Inorganic and nuclear chemistry
Impakt faktor: 5.3, rok: 2022
Způsob publikování: Open access
The antibacterial performance and cytotoxic examination of in situ prepared silver nanoparticles (Ag NPs), on inorganic-organic hybrid nanopowder consisting of zirconium dioxide nanoparticles (ZrO2 NPs) and dihydroquercetin (DHQ), was performed against Gram (-) bacteria Escherichia coli and Gram (+) bacteria Staphylococcus aureus, as well as against human cervical cancer cells HeLa and healthy MRC-5 human cells. The surface modification of ZrO2 NPs, synthesized by the sol-gel method, with DHQ leads to the interfacial charge transfer (ICT) complex formation indicated by the appearance of absorption in the visible spectral range. The prepared samples were thoroughly characterized (TEM, XRD, reflection spectroscopy), and, in addition, the spectroscopic observations are supported by the density functional theory (DFT) calculations using a cluster model. The concentration- and time-dependent antibacterial tests indicated a complete reduction of bacterial species, E. coli and S. aureus, for all investigated concentrations of silver (0.10, 0.25, and 0.50 mg/mL) after 24 h of contact. On the other side, the functionalized ZrO2 NPs with DHQ, before and after deposition of Ag NPs, do not display a significant decrease in the viability of HeLa MRC-5 cells in any of the used concentrations compared to the control.
Trvalý link: https://hdl.handle.net/11104/0334374
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