Počet záznamů: 1
Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation
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SYSNO ASEP 0559864 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation Tvůrce(i) Novotná, L. (CZ)
Chlup, Zdeněk (UFM-A) RID, ORCID
Jaroš, J. (CZ)
Částková, K. (CZ)
Drdlík, D. (CZ)
Pospíšil, J. (CZ)
Hampl, A. (CZ)
Koutná, I. (CZ)
Cihlář, J. (CZ)Celkový počet autorů 9 Zdroj.dok. Journal of Asian Ceramic Societies. - : Taylor & Francis - ISSN 2187-0764
Roč. 10, č. 2 (2022), s. 356-369Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Bioceramics ; scaffold ; calcium phosphate ; silica ; compressive strength Vědní obor RIV JI - Kompozitní materiály Obor OECD Ceramics Výzkumná infrastruktura CzechNanoLab - 90110 - Vysoké učení technické v Brně Způsob publikování Open access Institucionální podpora UFM-A - RVO:68081723 UT WOS 000773431900001 EID SCOPUS 85127222302 DOI 10.1080/21870764.2022.2053278 Anotace The positive effect of silica on microstructural, mechanical and biological properties of calcium phosphate scaffolds was investigated in this study. Scaffolds containing 3D interconnected spherical macropores with diameters in the range of 300-770 mu m were prepared by the polymer replica technique. Reinforcement was achieved by incorporating 5 to 20 wt % of colloidal silica into the initial hydroxyapatite (HA) powder. The HA was fully decomposed into alpha and beta-tricalcium phosphate, and silica was transformed into cristobalite at 1200 degrees C. Silica reinforced scaffolds exhibited compressive strength in the range of 0.3 to 30 MPa at the total porosity of 98-40%. At a nominal porosity of 75%, the compressive strength was doubled compared to scaffolds without silica. When immersed into a cultivation medium, the formation of an apatite layer on the surfaces of scaffolds indicated their bioactivity. The supportive effect of the silicon enriched scaffolds was examined using three different types of cells (human adipose-derived stromal cells, L929, and ARPE-19 cells). The cells firmly adhered to the surfaces of composite scaffolds with no sign of induced cell death. Scaffolds were non-cytotoxic and had good biocompatibility in vitro. They are promising candidates for therapeutic applications in regenerative medicine. Pracoviště Ústav fyziky materiálu Kontakt Yvonna Šrámková, sramkova@ipm.cz, Tel.: 532 290 485 Rok sběru 2023 Elektronická adresa https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278
Počet záznamů: 1