Počet záznamů: 1
Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting
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SYSNO ASEP 0545464 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting Tvůrce(i) Černotová, Daniela (FGU-C) ORCID
Stuchlík, Aleš (FGU-C) RID, ORCID
Svoboda, Jan (FGU-C) RID, ORCIDČíslo článku 107477 Zdroj.dok. Neurobiology of Learning and Memory. - : Elsevier - ISSN 1074-7427
Roč. 183, September 2021 (2021)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova behavioral flexibility ; ventral hippocampus ; prefrontal cortex ; Muscimol ; rotating arena ; carousel Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP NV17-30833A GA MZd - Ministerstvo zdravotnictví GA20-00939S GA ČR - Grantová agentura ČR LTAUSA19135 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000681199700009 EID SCOPUS 85107988227 DOI 10.1016/j.nlm.2021.107477 Anotace Neural components enabling flexible cognition and behavior are well-established, and depend mostly on proper intercommunication within the prefrontal cortex (PFC) and striatum. However, dense projections from the ventral hippocampus (vHPC) alter the functioning of the medial PFC (mPFC). Dysfunctional hippocampo-prefrontal connectivity negatively affects the integrity of flexible cognition, especially in patients with schizophrenia. In this study, we aimed to test the role of the vHPC and mPFC in a place avoidance task on a rotating arena using two spatial flexibility task variants – reversal learning and set-shifting. To achieve this, we inactivated each of these structures in adult male Long-Evans rats by performing bilateral local muscimol (a GABAA receptor agonist) injections. A significantly disrupted performance was observed in reversal learning in the vHPC-inactivated, but not in the mPFC-inactivated rats. These results confirm the notion that the vHPC participates in some forms of behavioral flexibility, especially when spatial cues are needed. It seems, rather unexpectedly, that the mPFC is not taxed in these flexibility tasks on a rotating arena. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://doi.org/10.1016/j.nlm.2021.107477
Počet záznamů: 1