Počet záznamů: 1
Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles
- 1.
SYSNO ASEP 0544174 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles Tvůrce(i) Gorshkova, Y. (RU)
Barbinta-Patrascu, M.-E. (RO)
Bokuchava, G. (RU)
Badea, N. (RO)
Ungureanu, C. (RO)
Lazea-Stoyanova, A. (RO)
Raileanu, M. (RO)
Bacalum, M. (RO)
Turchenko, V. (RU)
Zhigunov, Alexander (UMCH-V) RID, ORCID
Juszyńska-Galazka, E. (PL)Číslo článku 1811 Zdroj.dok. Nanomaterials. - : MDPI
Roč. 11, č. 7 (2021)Poč.str. 25 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova silver/silver chloride nanoparticles ; “green” synthesis ; chlorophyll-a-labeled bio-inspired membranes Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000676478400001 EID SCOPUS 85109472738 DOI 10.3390/nano11071811 Anotace Silver/silver chloride nanoparticles (Ag/AgClNPs), with a mean size of 48.2 ± 9.5 nm and a zeta potential value of −31.1 ± 1.9 mV, obtained by the Green Chemistry approach from a mixture of nettle and grape extracts, were used as “building blocks” for the “green” development of plasmonic biohybrids containing biomimetic membranes and chitosan. The mechanism of biohybrid formation was elucidated by optical analyses (UV–vis absorption and emission fluorescence, FTIR, XRD, and SAXS) and microscopic techniques (AFM and SEM). The aforementioned novel materials showed a free radical scavenging capacity of 75% and excellent antimicrobial properties against Escherichia coli (IGZ = 45 mm) and Staphylococcus aureus (IGZ = 35 mm). The antiproliferative activity of biohybrids was highlighted by a therapeutic index value of 1.30 for HT-29 cancer cells and 1.77 for HepG2 cancer cells. At concentrations below 102.2 µM, these materials are not hemolytic, so they will not be harmful when found in the bloodstream. In conclusion, hybrid systems based on phyto-Ag/AgClNPs, artificial cell membranes, and chitosan can be considered potential adjuvants in liver and colorectal cancer treatment. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2079-4991/11/7/1811
Počet záznamů: 1