Počet záznamů: 1
Synthesis and biological activity of brassinosteroid analogues with a nitrogen-containing side chain
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SYSNO ASEP 0543685 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis and biological activity of brassinosteroid analogues with a nitrogen-containing side chain Tvůrce(i) Diachkov, Mikhail V. (UEB-Q)
Ferrer, Karoll (UEB-Q) ORCID
Oklešťková, Jana (UEB-Q) RID, ORCID, SAI
Rárová, Lucie (UEB-Q) RID, ORCID
Bazgier, Václav (UEB-Q) ORCID, RID
Kvasnica, Miroslav (UEB-Q) RID, ORCIDCelkový počet autorů 6 Číslo článku 155 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 1 (2021)Poč.str. 27 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Brassinosteroid ; Cytotoxicity ; Nitrogen-containing steroid ; Organic synthesis ; Plant bioassay Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry CEP GA19-01383S GA ČR - Grantová agentura ČR EF16_019/0000827 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000606229400001 EID SCOPUS 85098771484 DOI 10.3390/ijms22010155 Anotace Brassinosteroids are a class of plant hormones that regulate a broad range of physiological processes such as plant growth, development and immunity, including the suppression of biotic and abiotic stresses. In this paper, we report the synthesis of new brassinosteroid analogues with a nitrogen-containing side chain and their biological activity on Arabidopis thaliana. Based on molecular docking experiments, two groups of brassinosteroid analogues were prepared with short and long side chains in order to study the impact of side chain length on plants. the derivatives with a short side chain were prepared with amide, amine and ammonium functional groups. the derivatives with a long side chain were synthesized using amide and ammonium functional groups. A total of 25 new brassinosteroid analogues were prepared. All 25 compounds were tested in an Arabidopsis root sensitivity bioassay and cytotoxicity screening. the synthesized substances showed no signifi-cant inhibitory activity compared to natural 24-epibrassinolide. In contrast, in low concentration, several compounds (8a, 8b, 8e, 16e, 22a and 22e) showed interesting growth-promoting activity. the cytotoxicity assay showed no toxicity of the prepared compounds on cancer and normal cell lines. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2022 Elektronická adresa http://doi.org/10.3390/ijms22010155
Počet záznamů: 1