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PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging
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SYSNO ASEP 0543052 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging Tvůrce(i) Kostiv, Uliana (UMCH-V) RID
Natile, M. M. (IT)
Jirák, D. (CZ)
Půlpánová, D. (CZ)
Jiráková, K. (CZ)
Vosmanská, M. (CZ)
Horák, Daniel (UMCH-V) RID, ORCIDZdroj.dok. ACS Omega. - : American Chemical Society - ISSN 2470-1343
Roč. 6, č. 22 (2021), s. 14420-14429Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova upconverting ; nanoparticles ; core-shell Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA19-00676S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000661452700046 EID SCOPUS 85108823448 DOI 10.1021/acsomega.1c01313 Anotace Upconverting nanoparticles are attracting extensive interest as a multimodal imaging tool. In this work, we report on the synthesis and characterization of gadolinium-enriched upconverting nanoparticles for bimodal magnetic resonance and optical luminescence imaging. NaYF4:Gd3+,Yb3+,Tm3+ core upconverting nanoparticles were obtained by a thermal coprecipitation of lanthanide oleate precursors in the presence of oleic acid as a stabilizer. With the aim of improving the upconversion emission and increasing the amount of Gd3+ ions on the nanoparticle surface, a 2.5 nm NaGdF4 shell was grown by the epitaxial layer-by-layer strategy, resulting in the 26 nm core–shell nanoparticles. Both core and core–shell nanoparticles were coated with poly(ethylene glycol) (PEG)-neridronate (PEG-Ner) to have stable and well-dispersed upconverting nanoparticles in a biological medium. FTIR spectroscopy and thermogravimetric analysis indicated the presence of ∼20 wt % of PEG-Ner on the nanoparticle surface. The addition of inert NaGdF4 shell resulted in a total 26-fold enhancement of the emission under 980 nm excitation and also affected the T1 and T2 relaxation times. Both r1 and r2 relaxivities of PEG-Ner-modified nanoparticles were much higher compared to those of non-PEGylated particles, thus manifesting their potential as a diagnostic tool for magnetic resonance imaging. Together with the enhanced luminescence efficiency, upconverting nanoparticles might represent an efficient probe for bimodal in vitro and in vivo imaging of cells in regenerative medicine, drug delivery, and/or photodynamic therapy. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://pubs.acs.org/doi/10.1021/acsomega.1c01313
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