Počet záznamů: 1  

Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system

  1. 1.
    SYSNO ASEP0539953
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevPostnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system
    Tvůrce(i) Svobodová Buriánová, Jana (UEM-P)
    Syka, Josef (UEM-P) RID
    Zdroj.dok.Brain Structure and Function. - : Springer - ISSN 1863-2653
    Roč. 225, č. 7 (2020), s. 1979-1995
    Poč.str.17 s.
    Jazyk dok.eng - angličtina
    Země vyd.DE - Německo
    Klíč. slovaenriched environment ; critical period ; dendrites
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    Obor OECDNeurosciences (including psychophysiology
    CEPEF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    LTAIN19201 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Způsob publikováníOmezený přístup
    Institucionální podporaUEM-P - RVO:68378041
    UT WOS000543316000001
    EID SCOPUS85087059597
    DOI10.1007/s00429-020-02104-8
    AnotaceThe structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat pups. AEE consisted of a spectrally and temporally modulated sound of moderate intensity, reinforced by a behavioral paradigm. At the age of 3-6 months, a Golgi-Cox staining was used to evaluate the morphology of neurons in the inferior colliculus (IC), the medial geniculate body (MGB), and the auditory cortex (AC). Compared to controls, rats exposed to AEE showed an increased mean dendritic length and volume and the soma surface in the external cortex and the central nucleus of the IC. The spine density increased in both the ventral and dorsal divisions of the MGB. In the AC, the total length and volume of the basal dendritic segments of pyramidal neurons and the number and density of spines on these dendrites increased significantly. No differences were found on apical dendrites. We also found an elevated number of spines and spine density in non-pyramidal neurons. These results show that exposure to AEE during the critical developmental period can induce permanent changes in the structure of neurons in the central auditory system. These changes represent morphological correlates of the functional plasticity, such as an improvement in frequency tuning and synchronization with temporal parameters of acoustical stimuli.
    PracovištěÚstav experimentální medicíny
    KontaktLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Rok sběru2021
    Elektronická adresahttps://link.springer.com/article/10.1007%2Fs00429-020-02104-8
Počet záznamů: 1  

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