Počet záznamů: 1
Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm
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SYSNO ASEP 0535623 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm Tvůrce(i) Bočková, M. (CZ)
Lamoš, M. (CZ)
Klimeš, Petr (UPT-D) RID, ORCID, SAI
Jurák, Pavel (UPT-D) RID, ORCID, SAI
Halámek, Josef (UPT-D) RID, ORCID, SAI
Goldemundová, S. (CZ)
Baláž, M. (CZ)
Rektor, I. (CZ)Celkový počet autorů 8 Zdroj.dok. Journal of Neural Transmission. - : Springer - ISSN 0300-9564
Roč. 127, č. 12 (2020), s. 1579-1588Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. AT - Rakousko Klíč. slova HD-EEG ; deep brain stimulation ; reaction time ; time frequency analysis ; biomarkers Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Medical engineering CEP NV16-33798A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora UPT-D - RVO:68081731 UT WOS 000572342400001 EID SCOPUS 85091386861 DOI 10.1007/s00702-020-02254-3 Anotace Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS off and on conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS on state than in the DBS off state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS on condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS. Pracoviště Ústav přístrojové techniky Kontakt Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Rok sběru 2021 Elektronická adresa https://link.springer.com/article/10.1007/s00702-020-02254-3
Počet záznamů: 1