Počet záznamů: 1
Nuclear Phosphoinositides and Phase Separation: Important Players in Nuclear Compartmentalization
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SYSNO ASEP 0523064 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Nuclear Phosphoinositides and Phase Separation: Important Players in Nuclear Compartmentalization Tvůrce(i) Sztacho, Martin (UMG-J) ORCID
Sobol, Margaryta (UMG-J) RID
Balaban, Can (UMG-J)
Escudeiro Lopes, Sara Eliana (UMG-J) ORCID
Hozák, Pavel (UMG-J) RID, ORCIDZdroj.dok. Advances in Biological Regulation. - : Elsevier - ISSN 2212-4926
Roč. 71, January (2019), s. 111-117Poč.str. 7 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Nuclear architecture ; Nucleus ; Phase separation ; Phosphoinositides ; Transcription Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA16-03346S GA ČR - Grantová agentura ČR GA17-09103S GA ČR - Grantová agentura ČR TE01020118 GA TA ČR - Technologická agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LO1419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UMG-J - RVO:68378050 DOI 10.1016/j.jbior.2018.09.009 Anotace Nuclear phosphoinositides are recognized as regulators of many nuclear processes including chromatin remodeling, splicing, transcription, DNA repair and epigenetics. These processes are spatially organized in different nuclear compartments. Phase separation is involved in the formation of various nuclear compartments and molecular condensates separated from surrounding environment. The surface of such structures spatiotemporally coordinates formation of protein complexes. PI(4,5)P2 (PIP2) integration into phase-separated structures might provide an additional step in their spatial diversification by attracting certain proteins with affinity to PIP2. Our laboratory has recently identified novel membrane-free PIP2-containing structures, so called Nuclear Lipid Islets (NLIs). We provide an evidence that these structures are evolutionary conserved in different organisms. We hypothesize that NLIs serve as a scaffolding platform which facilitates the formation of transcription factories, thus participating in the formation of nuclear architecture competent for transcription. In this review we speculate on a possible role of NLIs in the integration of various processes linked to RNAPII transcription, chromatin remodeling, actin-myosin interaction, alternative splicing and lamin structures. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/abs/pii/S2212492618301313?via%3Dihub
Počet záznamů: 1