Počet záznamů: 1
Lifestyle and dietary environmental factors in colorectal cancer susceptibility
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SYSNO ASEP 0517915 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lifestyle and dietary environmental factors in colorectal cancer susceptibility Tvůrce(i) Murphy, N. (FR)
Moreno, V. (ES)
Hughes, D. J. (IE)
Vodičková, Ludmila (UEM-P) RID
Vodička, Pavel (UEM-P) RID
Aglago, E.K. (FR)
Gunter, M.J. (FR)
Jenab, M. (FR)Zdroj.dok. Molecular Aspects of Medicine. - : Elsevier - ISSN 0098-2997
Roč. 69, SI (2019), s. 2-9Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova colorectal cancer ; environment ; diet Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Oncology CEP GA18-09709S GA ČR - Grantová agentura ČR NV15-27580A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora UEM-P - RVO:68378041 UT WOS 000486385900002 EID SCOPUS 85067993618 DOI 10.1016/j.mam.2019.06.005 Anotace Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particularly lifestyle and diet. It is established that physical inactivity, obesity and some dietary factors (red/processed meats, alcohol) are positively associated with CRC, while healthy lifestyle habits show inverse associations. Mechanistic evidence shows that lifestyle and dietary components that contribute to energy excess are linked with increased CRC via metabolic dysfunction, inflammation, oxidative stress, bacterial dysbiosis and breakdown of gut barrier integrity while the reverse is apparent for components associated with decreased risk. This chapter will review the available evidence on lifestyle and dietary factors in CRC etiology and their underlying mechanisms in CRC development. This short review will also touch upon available information on potential gene-environment interactions, molecular sub-types of CRC and anatomical sub-sites within the colorectum. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0098299719300330?via%3Dihub
Počet záznamů: 1