Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication

0517251 - ÚFCH JH 2020 RIV AT eng J - Článek v odborném periodiku
Klučka, J. - Juřenčák, T. - Kosinová, M. - Petr, Š. - Kratochvíl, M. - Sedláčková, Y. - Navrátil, Tomáš - Pelclová, D. - Jabandžiev, P.
Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication.
Monatshefte fur Chemie. Roč. 150, č. 9 (2019), s. 1711-1714. ISSN 0026-9247. E-ISSN 1434-4475
Institucionální podpora: RVO:61388955
Klíčová slova: Antipsychotic drug intoxication * Life-threatening arrhythmia * Lipid resuscitation * Paediatric patient
Obor OECD: Physical chemistry
Impakt faktor: 1.349, rok: 2019
Způsob publikování: Omezený přístup

We present a case of the acute intoxication of a 17-year-old patient after ingestion of 6 g of quetiapine in combination with 1 g of lamotrigine. Due to the severe tachycardia, hypertension, and prolonged QTc without improvement after standard treatment, the patient was treated with Intralipid 20% intravenous infusion recommended by the Toxicologic Information Centre. After lipid infusion, the QTc rapidly normalised and tachycardia resolved to sinus rhythm. The patient was transferred to psychiatry intensive care on the third day after admission.
Trvalý link: http://hdl.handle.net/11104/0302548