Počet záznamů: 1
Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats: The Role of Sympathetic Nervous System
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SYSNO ASEP 0492836 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats: The Role of Sympathetic Nervous System Tvůrce(i) Behuliak, Michal (FGU-C) RID, ORCID
Bencze, Michal (FGU-C) RID, ORCID, SAI
Polgárová, Kamila (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Vaněčková, Ivana (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAIZdroj.dok. Hypertension. - : Lippincott Williams & Wilkins - ISSN 0194-911X
Roč. 72, č. 3 (2018), s. 676-685Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova baroreflex ; calcium channels ; gabapentin ; sympathectomy ; sympathetic nervous system Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie Obor OECD Cardiac and Cardiovascular systems CEP GJ16-10349Y GA ČR - Grantová agentura ČR GP14-16225P GA ČR - Grantová agentura ČR NV15-25396A GA MZd - Ministerstvo zdravotnictví Institucionální podpora FGU-C - RVO:67985823 UT WOS 000441024000030 EID SCOPUS 85055600777 DOI 10.1161/HYPERTENSIONAHA.118.09909 Anotace Ligands of auxiliary (2) subunit of voltage-dependent calcium channels (VDCCs) decrease elevated L-type VDCCs surface expression in arterial myocytes and arterial constriction in spontaneously hypertensive rats (SHR). However, their effect on blood pressure (BP) is unclear. In this study, we investigated the hemodynamic response to acute and chronic administration of gabapentin, a ligand of auxiliary (2) subunit of VDCCs, in adult SHR with established neurogenic hypertension. The acute gabapentin administration lowered BP and heart rate more in conscious SHR than Wistar-Kyoto rats. Both nifedipine (L-type VDCCs blocker) and -conotoxin GVIA (N-type VDCCs blocker) also decreased BP more in SHR, but only gabapentin and -conotoxin GVIA abolished the nitroprusside-induced reflex tachycardia of baroreceptor-heart rate control. Hypotensive effect of gabapentin was accompanied by a reduction of (1) plasma norepinephrine level, (2) depressor response to ganglionic blocker pentolinium, (3) power of low frequency component of systolic BP variability, and (4) pressor response of mesenteric vascular bed to periarterial nerve stimulation, suggesting the decrease of peripheral sympathetic nerve transmission. Moreover, gabapentin effects on BP and baroreflex were absent in sympathectomized rats. In conclusion, the acute (but not chronic) administration of gabapentin lowered BP more in SHR than in Wistar-Kyoto rats. Besides the known L-type VDCCs involvement in the vascular effect of gabapentin, our data revealed the important role of N-type VDCCs in acute gabapentin effect on sympathetic control of BP. Gabapentin-induced changes of sympathetic nerve transmission indicated major hemodynamic mechanism of the acute response to this drug. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
Počet záznamů: 1