Počet záznamů: 1
Signatures of diversifying selection and convergence acting on passerine Toll‐like receptor 4 in an evolutionary context
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SYSNO ASEP 0490181 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Signatures of diversifying selection and convergence acting on passerine Toll‐like receptor 4 in an evolutionary context Tvůrce(i) Králová, Tereza (UBO-W) ORCID
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Bryja, Josef (UBO-W) RID, SAI, ORCID
Hořák, D. (CZ)
Johnsen, A. (NO)
Lifjeld, J. T. (NO)
Novotný, M. (CZ)
Sedláček, O. (CZ)
Velová, H. (CZ)
Vinkler, M. (CZ)Celkový počet autorů 10 Zdroj.dok. Molecular Ecology. - : Wiley - ISSN 0962-1083
Roč. 27, č. 13 (2018), s. 2871-2883Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova functional evolution ; host–pathogen interaction ; surface charge distribution ; TLR4 molecular phenotype ; Toll-like receptors Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP GA17-24782S GA ČR - Grantová agentura ČR GA15-11782S GA ČR - Grantová agentura ČR Institucionální podpora UBO-W - RVO:68081766 UT WOS 000436113300008 EID SCOPUS 85048986837 DOI 10.1111/mec.14724 Anotace Positive selection acting on Toll‐like receptors (TLRs) has been recently investigated to reveal evolutionary mechanisms of host–pathogen molecular co‐adaptation. Much of this research, however, has focused mainly on the identification of sites predicted to be under positive selection, bringing little insight into the functional differences and similarities among species and a limited understanding of convergent evolution in the innate immune molecules. In this study, we provide evidence of phenotypic variability in the avian TLR4 ligand‐binding region (LBR), the direct interface between host and pathogen molecular structures. We show that 55 passerine species vary substantially in the distribution of electrostatic potential on the surface of the receptor, and based on these distinct patterns, we identified four species clusters. Seven of the 34 evolutionarily nonconservative and positively selected residues correspond topologically to sites previously identified as being important for lipopolysaccharide, lipid IVa or MD‐2 binding. Five of these positions codetermine the identity of the charge clusters. Groups of species that host‐related communities of pathogens were predicted to cluster based on their TLR4 LBR charge. Despite some evidence for convergence among taxa, there were no clear associations between the TLR4 LBR charge distribution and any of the general ecological characteristics compared (migration, latitudinal distribution and diet). Closely related species, however, mostly belonged to the same surface charge cluster indicating that phylogenetic constraints are key determinants shaping TLR4 adaptive evolution. Our results suggest that host innate immune evolution is consistent with Fahrenholz's rule on the cospeciation of hosts and their parasites. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2018
Počet záznamů: 1