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Nanostructure of hyaluronan acyl-derivatives in the solid state
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SYSNO ASEP 0489374 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Nanostructure of hyaluronan acyl-derivatives in the solid state Tvůrce(i) Chmelař, J. (CZ)
Bělský, P. (CZ)
Mrázek, J. (CZ)
Švadlák, D. (CZ)
Hermannová, M. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Krakovský, I. (CZ)
Šmejkalová, D. (CZ)
Velebný, V. (CZ)Zdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 195, 1 September (2018), s. 468-475Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova hyaluronan ; hydrophobization ; nanostructure Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP TE01020118 GA TA ČR - Technologická agentura ČR Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000433204900053 EID SCOPUS 85046735008 DOI 10.1016/j.carbpol.2018.04.111 Anotace Acyl derivatives of hyaluronan (acyl-HA) are promising materials for biomedical applications. Depending on the acyl length and the degree of substitution, these derivatives range from self-assembling water-soluble polymers to materials insoluble in aqueous environments. The behaviour of acyl-HA was studied in solution, but little attention was paid to the solid state, despite its importance for applications such as medical device fabrication. We thus used X-ray scattering and electron microscopy to explore the solid-state nano-structure of acyl-HA. The set of samples included various substituents, substitution degrees and molecular weights. The obtained data showed that all studied acyl-HA materials contained structures with dimensions on the order of nanometres that were not present in unmodified HA. The size of the nanostructures increased with the acyl length, while the degree of substitution and molecular weight had negligible effects. We suggest that the observed nanostructure corresponds to a distribution of hydrophobic domains in a hydrophilic matrix of unmodified HA segments. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2019
Počet záznamů: 1