Počet záznamů: 1
Recent progress in electrochemical sensors and assays for DNA damage and repair
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SYSNO ASEP 0471986 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Recent progress in electrochemical sensors and assays for DNA damage and repair Tvůrce(i) Fojta, Miroslav (BFU-R) RID, ORCID
Daňhel, Aleš (BFU-R) RID, ORCID
Havran, Luděk (BFU-R) RID, ORCID
Vyskočil, V. (CZ)Celkový počet autorů 4 Zdroj.dok. TrAC-Trends in Analytical Chemistry. - : Elsevier - ISSN 0165-9936
Roč. 79, MAY2016 (2016), s. 160-167Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova in-situ evaluation ; carbon-paste electrode ; voltammetric detection Vědní obor RIV BO - Biofyzika CEP GBP206/12/G151 GA ČR - Grantová agentura ČR Institucionální podpora BFU-R - RVO:68081707 UT WOS 000376703900016 DOI 10.1016/j.trac.2015.11.018 Anotace DNA in cells is permanently exposed to endogenous or exogenous chemical or physical agents which may cause chemical changes in the DNA structure collectively called "DNA damage", which may have severe impacts on human health. Therefore, efficient techniques to detect DNA damage are sought, among which electroanalytical methods hold an important position. This review is focused on recent progress in the field of electrochemical sensors and assays for DNA damage, particularly on typical applications of advanced electrochemical techniques in detecting oxidative DNA damage, abasic lesions, base mismatches, non-covalent interactions with drugs and other substances. Special attention is paid to combinations of electrochemical detection with biochemical tools such as enzymatic systems mimicking metabolic activation of xenobiotics, or DNA repair enzymes converting specific nucleobase lesions to species offering more facile electrochemical detection. These applications create conditions for application of electroanalytical approaches in biological research, including studies of DNA repair processes. (C) 2015 Elsevier B.V. All rights reserved. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2017
Počet záznamů: 1