Počet záznamů: 1
Epigenetics and a new look on metabolic syndrome
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SYSNO ASEP 0455409 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Epigenetics and a new look on metabolic syndrome Tvůrce(i) Kuneš, Jaroslav (UOCHB-X) ORCID, RID
Vaněčková, I. (CZ)
Mikulášková, Barbora (UOCHB-X)
Behuliak, M. (CZ)
Maletínská, Lenka (UOCHB-X) RID, ORCID
Zicha, J. (CZ)Celkový počet autorů 6 Zdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, č. 5 (2015), s. 611-620Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova metabolic syndrome ; epigenetics ; transgenerational inheritance ; gene-environmental interactions ; obesity ; hypertension Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa CEP GA15-08679S GA ČR - Grantová agentura ČR Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000367154800003 EID SCOPUS 84983151089 Anotace The incidence of metabolic syndrome increases in the developed countries, therefore biomedical research is focused on the understanding of its etiology. The study of exact mechanisms is very complicated because both genetic and environmental factors contribute to this complex disease. The ability of environmental factors to promote phenotype changes by epigenetic DNA modifications (i.e. DNA methylation, histone modifications) was demonstrated to play an important role in the development and predisposition to particular symptoms of metabolic syndrome. There is no doubt that the early life, such as the fetal and perinatal periods, is critical for metabolic syndrome development and therefore critical for prevention of this disease. Moreover, these changes are visible not only in individuals exposed to environmental factors but also in the subsequent progeny for multiple generations and this phenomenon is called transgenerational inheritance. The knowledge of molecular mechanisms, by which early minor environmental stimuli modify the expression of genetic information, might be the desired key for the understanding of mechanisms leading to the change of phenotype in adulthood. This review provides a short overview of metabolic syndrome epigenetics. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2016 Elektronická adresa http://www.biomed.cas.cz/physiolres/pdf/64/64_611.pdf
Počet záznamů: 1