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The Extreme Anterior Domain Is an Essential Craniofacial Organizer Acting through Kinin-Kallikrein Signaling
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SYSNO ASEP 0441368 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Extreme Anterior Domain Is an Essential Craniofacial Organizer Acting through Kinin-Kallikrein Signaling Tvůrce(i) Jacox, L. (US)
Šindelka, Radek (BTO-N) RID
Chen, J. (US)
Rothman, A. (US)
Dickinson, A. (US)
Sive, H. (US)Zdroj.dok. Cell Reports. - : Cell Press - ISSN 2211-1247
Roč. 8, č. 2 (2014), s. 595-608Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova CRANIAL NEURAL CREST ; NITRIC-OXIDE SYNTHASE ; XENOPUS-LAEVIS Vědní obor RIV EB - Genetika a molekulární biologie Institucionální podpora BTO-N - RVO:86652036 UT WOS 000341569800027 DOI 10.1016/j.celrep.2014.06.026 Anotace The extreme anterior domain (EAD) is a conserved embryonic region that includes the presumptive mouth. We show that the Kinin-Kallikrein pathway is active in the EAD and necessary for craniofacial development in Xenopus and zebrafish. The mouth failed to form and neural crest (NC) development and migration was abnormal after loss of function (LOF) in the pathway genes kng, encoding Bradykinin (xBdk), carboxypeptidase-N (cpn), which cleaves Bradykinin, and neuronal nitric oxide synthase (nNOS). Consistent with a role for nitric oxide (NO) in face formation, endogenous NO levels declined after LOF in pathway genes, but these were restored and a normal face formed after medial implantation of xBdk-beads into LOF embryos. Facial transplants demonstrated that Cpn function from within the EAD is necessary for the migration of first arch cranial NC into the face and for promoting mouth opening. The study identifies the EAD as an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2015
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