Počet záznamů: 1  

An Epigenetic Model for Pigment Patterning Based on Mechanical and Cellular Interactions

  1. 1.
    SYSNO ASEP0385246
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAn Epigenetic Model for Pigment Patterning Based on Mechanical and Cellular Interactions
    Tvůrce(i) Caballero, L. (CZ)
    Benitez, M. (CZ)
    Alvarez-Buylla, E. R. (MX)
    Hernandez, S. (MX)
    Arzola, Alejandro V. (UPT-D) RID, SAI
    Cocho, G. (MX)
    Celkový počet autorů6
    Zdroj.dok.Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. - : Wiley - ISSN 1552-5007
    Roč. 318, č. 3 (2012), s. 209-223
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaepithelial-mesenchymal transitions ; neural crest ; traction forces ; morphogenesis
    Vědní obor RIVED - Fyziologie
    Institucionální podporaUPT-D - RVO:68081731
    UT WOS000303313800007
    DOI https://doi.org/10.1002/jez.b.22007
    AnotacePigment patterning in animals generally occurs during early developmental stages and has ecological, physiological, ethological, and evolutionary significance. Despite the relative simplicity of color patterns, their emergence depends upon multilevel complex processes. Thus, theoretical models have become necessary tools to further understand how such patterns emerge. Recent studies have reevaluated the importance of epigenetic, as well as genetic factors in developmental pattern formation. Yet epigenetic phenomena, specially those related to physical constraints that might be involved in the emergence of color patterns, have not been fully studied. In this article, we propose a model of color patterning in which epigenetic aspects such as cell migration, celltissue interactions, and physical and mechanical phenomena are central. This model considers that motile cells embedded in a fibrous, viscoelastic matrixmesenchymecan deform it in such a way that tension tracks are formed. We postulate that these tracks act, in turn, as guides for subsequent cell migration and establishment, generating long-range phenomenological interactions. We aim to describe some general aspects of this developmental phenomenon with a rather simple mathematical model. Then we discuss our model in the context of available experimental and morphological evidence for reptiles, amphibians, and fishes, and compare it with other patterning models. We also put forward novel testable predictions derived from our model, regarding, for instance, the localization of the postulated tension tracks, and we propose new experiments. Finally, we discuss how the proposed mechanism could constitute a dynamic patterning module accounting for pattern formation in many animal lineages.
    PracovištěÚstav přístrojové techniky
    KontaktMartina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178
    Rok sběru2013
Počet záznamů: 1  

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