Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter

0377359 - FGÚ 2013 RIV NL eng J - Článek v odborném periodiku
Zahrádka, Jaromír - Van Heusden, G.P.H. - Sychrová, Hana
Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter.
Biochimica et Biophysica Acta-General Subjects. Roč. 1820, č. 7 (2012), s. 849-858. ISSN 0304-4165. E-ISSN 1872-8006
Grant CEP: GA MŠMT(CZ) LC531; GA MŠMT(CZ) OC10012; GA AV ČR(CZ) IAA500110801
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: yeast * 14-3-3 proteins * ion homeostasis * Nha1 antiporter
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.848, rok: 2012

Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter
Trvalý link: http://hdl.handle.net/11104/0209534