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New strategies in synthesis of acyclic nucleoside phosphonate prodrugs
- 1.0361376 - ÚOCHB 2012 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Krečmerová, Marcela - Tichý, Tomáš - Blažek, Jiří - Pomeisl, Karel
New strategies in synthesis of acyclic nucleoside phosphonate prodrugs.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 163-166. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
Grant CEP: GA MŠMT 1M0508
Grant ostatní: NIH(US) 1UC1 AI062540-01
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: ester prodrugs * ANP * HATU * phophonates * PyBOP * PyBroP * glycosylation
Kód oboru RIV: CC - Organická chemie
New syntheses of acyclic nucleoside phosphonate prodrugs including dioxolenone derivatives, functionalized alkoxyalkyl esters, utilization of hexafluorophosphate coupling agents and enzymatic glycosylations were described. Comparison of antiviral activities of diverse prodrugs was performed.
Trvalý link: http://hdl.handle.net/11104/0198699
Počet záznamů: 1