Počet záznamů: 1
Integrating plant and animal biology for the search of novel DNA damage biomarkers
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SYSNO ASEP 0489222 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Integrating plant and animal biology for the search of novel DNA damage biomarkers Tvůrce(i) Nikitaki, Z. (GR)
Holá, Marcela (UEB-Q) ORCID
Donà, M. (AT)
Pavlopoulou, A. (GR)
Michalopoulos, I. (GR)
Angelis, Karel (UEB-Q) RID, ORCID
Georgakilas, A. G. (GR)
Macovei, I. (RO)
Balestrazzi, A. (IT)Celkový počet autorů 9 Zdroj.dok. Mutation Research-Reviews in Mutation Research. - : Elsevier - ISSN 1383-5742
Roč. 775, JAN-MAR (2018), s. 21-38Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova DNA damage response ; Ionizing radiation ; Radiation exposure monitoring ; Radiotolerance ; Ultraviolet radiation Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Genetics and heredity (medical genetics to be 3) CEP GA16-01137S GA ČR - Grantová agentura ČR Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000430034200003 EID SCOPUS 85041601506 DOI 10.1016/j.mrrev.2018.01.001 Anotace Eukaryotic genome surveillance is dependent on the multiple, highly coordinated network functions of the DNA damage response (DDR). Highlighted conserved features of DDR in plants and animals represent a challenging opportunity to develop novel interdisciplinary investigations aimed at expanding the sets of DNA damage biomarkers currently available for radiation exposure monitoring (REM) in environmental and biomedical applications. In this review, common and divergent features of the most relevant DDR players in animals and plants are described, including the intriguing example of the plant and animal kingdom-specific master regulators SOG1 (suppressor of gamma response) and p53. The potential of chromatin remodelers as novel predictive biomarkers of DNA damage is considered since these highly evolutionarily conserved proteins provide a docking platform for the DNA repair machinery. The constraints of conventional REM biomarkers can be overcome using biomarkers identified with the help of the pool provided by high-throughput techniques. The complexity of radiation-responsive animal and plant transcriptomes and their usefulness as sources of novel REM biomarkers are discussed, focusing on ionizing (IR) and UV-radiation. The possible advantages resulting from the exploitation of plants as sources of novel DNA damage biomarkers for monitoring the response to radiation-mediated genotoxic stress are listed. Plants could represent an ideal system for the functional characterization of knockout mutations in DDR genes which compromise cell survival in animals. However, the pronounced differences between plant and animal cells need to be carefully considered in order to avoid any misleading interpretations. Radioresistant plant-based systems might be useful to explore the molecular bases of LD (low dose)/LDR (low dose rate) responses since nowadays it is extremely difficult to perform an accurate assessment of LD/LDR risk to human health. To overcome these constraints, researchers have started exploring radiotolerant non-human species as potential sources of information on the mechanisms involved in LD/LDR and general radiation responses. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2019
Počet záznamů: 1