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Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2
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SYSNO ASEP 0127049 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2 Tvůrce(i) Bryja, V. (CZ)
Sedláček, J. (CZ)
Zahradníčková, E. (CZ)
Ševčíková, S. (CZ)
Pacherník, Jiří (BFU-R)
Souček, Karel (BFU-R) RID, ORCID
Hofmanová, Jiřina (BFU-R) RID, ORCID
Kozubík, Alois (BFU-R) RID, ORCID
Šmarda, J. (CZ)Zdroj.dok. Prostaglandins - ISSN 0090-6980
Roč. 72, 3-4 (2003), s. 131-145Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova hematopoiesis ; arachidonic acid ; lipoxygenase inhibitors Vědní obor RIV BO - Biofyzika CEP GA301/01/0040 GA ČR - Grantová agentura ČR GA524/03/0766 GA ČR - Grantová agentura ČR CEZ AV0Z5004920 - BFU-R Anotace Inhibitors of arachidonic acid (AA) conversion were described as suppressors of proliferation and inducers of differentiation of various leukemic cells. Certain AA metabolites have been shown to cooperate with Jun proteins that are important factors controlling cell proliferation, differentiation and apoptosis. Using lipoxygenase (LOX) inhibitors of various specifity we studied possible participation of lipoxygenase pathway in regulation of proliferation and apoptosis of v-myb-transformed chicken monoblasts BM2 and its functional interaction with Jun proteins. We found that nordihydroguaiaretic acid (NDGA) and esculetin (Esc) negatively regulate proliferation of BM2 cells causing accumulation in either G(0)/G(1)-phase (nordihydroguaiaretic acid) or S-phase (esculetin) of the cell cycle. BM2 cells can be also induced to undergo growth arrest and partial differentiation by ectopic expression of Jun proteins. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2004
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