Počet záznamů: 1
Exploring the application of poly(1,2-ethanediol citrate)/polylactide nonwovens in cell culturing
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SYSNO ASEP 0584926 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Exploring the application of poly(1,2-ethanediol citrate)/polylactide nonwovens in cell culturing Tvůrce(i) Bandzerewicz, A. (PL)
Howis, J. (PL)
Wierzchowski, K. (PL)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Hodan, Jiří (UMCH-V)
Denis, P. (PL)
Golofit, T. (PL)
Pilarek, M. (PL)
Gadomska-Gajadhur, A. (PL)Číslo článku 1332290 Zdroj.dok. Frontiers in Bioengineering and Biotechnology. - : Frontiers Media - ISSN 2296-4185
Roč. 12, 15 March (2024)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova citric acid ; citrate-based polyesters ; biomaterials Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001193121500001 EID SCOPUS 85188844655 DOI 10.3389/fbioe.2024.1332290 Anotace Biomaterials containing citric acid as a building unit show potential for use as blood vessel and skin tissue substitutes. The success in commercializing implants containing a polymer matrix of poly(1,8-octanediol citrate) provides a rationale for exploring polycitrates based on other diols. Changing the aliphatic chain length of the diol allows functional design strategies to control the implant’s mechanical properties, degradation profile and surface energy. In the present work, poly(1,2-ethanediol citrate) was synthesized and used as an additive to polylactide in the electrospinning process. It was established that the content of polycitrate greatly influences the nonwovens’ properties: an equal mass ratio of polymers resulted in the best morphology. The obtained nonwovens were characterized by surface hydrophilicity, tensile strength, and thermal properties. L929 cell cultures were carried out on their surface. The materials were found to be non-cytotoxic and the degree of porosity was suitable for cell colonization. On the basis of the most important parameters for assessing the condition of cultured cells (cell density and viability, cell metabolic activity and lactate dehydrogenase activity), the potential of PLLA + PECit nonwovens for application in tissue engineering was established. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fbioe.2024.1332290/full
Počet záznamů: 1