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Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?
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SYSNO ASEP 0584709 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells? Tvůrce(i) Rodriguez-Jiménez, F.J. (ES)
Urena-Peralta, J. (ES)
Jendelová, Pavla (UEM-P) RID, ORCID
Erceg, Slaven (UEM-P) RID, ORCIDZdroj.dok. Journal of Advanced Research - ISSN 2090-1232
Roč. 54, dec. (2023), s. 105-118Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. EG - Egypt Klíč. slova Induced pluripotent stem cells ; Alzheimer's disease ; Neurons ; Neural differentiation ; Brain organoids Obor OECD Neurosciences (including psychophysiology CEP EF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 001127856800001 EID SCOPUS 85147128554 DOI 10.1016/j.jare.2023.01.006 Anotace Background: Synaptic dysfunction is a major contributor to Alzheimer ' s disease (AD) pathogenesis in addition to the formation of neuritic b-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features contribute to synaptic dysfunction and axonal loss remains unclear. While years of considerable effort have been devoted to gaining an improved under -standing of this devastating disease, the unavailability of patient-derived tissues, considerable genetic heterogeneity, and lack of animal models that faithfully recapitulate human AD have hampered the development of effective treatment options. Ongoing progress in human induced pluripotent stem cell (hiPSC) technology has permitted the derivation of patient-and disease-specific stem cells with unlim-ited self-renewal capacity. These cells can differentiate into AD-affected cell types, which support studies of disease mechanisms, drug discovery, and the development of cell replacement therapies in traditional and advanced cell culture models.Aim of Review: To summarize current hiPSC-based AD models, highlighting the associated achievements and challenges with a primary focus on neuron and synapse loss.Key Scientific Concepts of Review: We aim to identify how hiPSC models can contribute to understanding AD-associated synaptic dysfunction and axonal loss. hiPSC-derived neural cells, astrocytes, and microglia, as well as more sophisticated cellular organoids, may represent reliable models to investigate AD and identify early markers of AD-associated neural degeneration.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S2090123223000061?via%3Dihub
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