Počet záznamů: 1
Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation
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SYSNO ASEP 0584540 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation Tvůrce(i) Gómez, I. J. (CZ)
Křížková, P. (CZ)
Dolečková, A. (CZ)
Cardo, L. (ES)
Wetzl, C. (ES)
Pizúrová, Naděžda (UFM-A) RID, ORCID
Prato, M. (ES)
Medalová, J. (CZ)
Zajíčková, L. (CZ)Celkový počet autorů 9 Číslo článku 102072 Zdroj.dok. Applied Materials Today. - : Elsevier - ISSN 2352-9407
Roč. 36, FEB (2024)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova carbon nano-onions ; abc transporters ; nanotubes ; memantine ; mechanism ; model ; size ; Carbon dots ; Memantine ; Protein aggregation ; Blood-brain barrier ; Bioimaging Výzkumná infrastruktura CzechNanoLab - 90110 - Vysoké učení technické v Brně Způsob publikování Open access Institucionální podpora UFM-A - RVO:68081723 UT WOS 001171819100001 EID SCOPUS 85183459574 DOI 10.1016/j.apmt.2024.102072 Anotace Multifunctional nanoparticles could be the hallmark for the treatment of neurodegenerative diseases. Dissociation of protein aggregates causing neuronal damage and transfer of specific drugs which can downregulate neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-D-Aspartate-receptors (NMDA) and then reducing calcium influx are among the main factors to consider for proper therapy. Here, we present a multiplatform based on nitrogen-doped graphene quantum dots (NGQDs) with such functionalities. The NGQDs were functionalized with Memantine, the clinically used drug, via covalent and non-covalent coupling, and we confirmed that the pharmaceutical activity was not altered. Apart from that, using xCELLigence technology and flow cytometric analysis of ABC transporter function, we uncovered that the ABC transporters of the blood-brain barrier (BBB) do not affect the ability of NGQD to cross BBB. Surprisingly, this study found that NGQDs have an inhibitory effect on NMDA receptors, thus supporting the action of Memantine. Moreover, NGQDs and their derivatives demonstrated the potential to dissociate beta-amyloid aggregates while possessing features suitable for bioimaging in various cell lines. Pracoviště Ústav fyziky materiálu Kontakt Yvonna Šrámková, sramkova@ipm.cz, Tel.: 532 290 485 Rok sběru 2025 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S2352940724000180?via%3Dihub
Počet záznamů: 1