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Holocentromeres can consist of merely a few megabase-sized satellite arrays
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SYSNO ASEP 0584244 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Holocentromeres can consist of merely a few megabase-sized satellite arrays Tvůrce(i) Kuo, Y. T. (DE)
Câmara, A. S. (DE)
Schubert, V. (DE)
Neumann, Pavel (BC-A) RID, ORCID
Macas, Jiří (BC-A) RID, ORCID, SAI
Melzer, M. (DE)
Chen, J. (DE)
Fuchs, J. (DE)
Abel, S. (DE)
Klocke, E. (DE)
Huettel, B. (DE)
Himmelbach, A. (DE)
Demidov, D. (DE)
Dunemann, F. (DE)
Mascher, M. (DE)
Ishii, T. (JP)
Marques, A. (DE)
Houben, A. (DE)Celkový počet autorů 18 Číslo článku 3502 Zdroj.dok. Nature Communications. - : Nature Publishing Group
Roč. 14, č. 1 (2023)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova nuclear-dna content ; histone h3 ; chionographis liliaceae ; luzula-elegans ; centromere ; chromosomes ; arabidopsis ; methylation ; euchromatin ; generation Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Genetics and heredity (medical genetics to be 3) CEP GA20-25440S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 001061547600036 EID SCOPUS 85161926507 DOI 10.1038/s41467-023-38922-7 Anotace The centromere is the chromosome region where microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere, holocentric species usually distribute hundreds of centromere units along the entire chromatid. We assembled the chromosome-scale reference genome and analyzed the holocentromere and (epi)genome organization of the lilioid Chionographis japonica. Remarkably, each of its holocentric chromatids consists of only 7 to 11 evenly spacedmegabase-sized centromere-specific histone H3-positive units. These units contain satellite arrays of 23 and 28 bp-long monomers capable of forming palindromic structures. Like monocentric species, C. japonica forms clustered centromeres in chromocenters at interphase. In addition, the large-scale eu- and heterochromatin arrangement differs between C. japonica and other known holocentric species. Finally, using polymer simulations, we model the formation of prometaphase line-like holocentromeres from interphase centromere clusters. Our findings broaden the knowledge about centromere diversity, showing that holocentricity is not restricted to species with numerous and small centromere units. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://www.nature.com/articles/s41467-023-38922-7
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