Počet záznamů: 1  

Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation

  1. 1.
    SYSNO ASEP0583536
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevCell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation
    Tvůrce(i) Perečko, Tomáš (BFU-R) RID, ORCID
    Perečková, Jana (BFU-R) ORCID
    Hoferová, Zuzana (BFU-R) RID
    Falk, Martin (BFU-R) RID, ORCID
    Celkový počet autorů4
    Zdroj.dok.Biological Chemistry. - : Walter de Gruyter - ISSN 1431-6730
    Roč. 2023, SEP 15 2023 (2023)
    Poč.str.11 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.DE - Německo
    Klíč. slovaconjugated linoleic-acid ; fatty-acids ; radiation ; oxide ; radiosensitivity ; apoptosis ; sensitivity
    Vědní obor RIVCE - Biochemie
    Obor OECDBiochemistry and molecular biology
    Způsob publikováníOmezený přístup
    Institucionální podporaBFU-R - RVO:68081707
    UT WOS001067412100001
    EID SCOPUS85171733621
    DOI10.1515/hsz-2023-0150
    AnotaceNitro-fatty acids (NFAs) are endogenous lipid mediators capable of post-translational modifications of selected regulatory proteins. Here, we investigated the anti-cancerous effects of nitro-oleic acid (NO(2)OA) and its combination with gamma irradiation on different cancer cell lines. The effects of NO(2)OA on cell death, cell cycle distribution, or expression of p21 and cyclin D1 proteins were analyzed in cancer (A-549, HT-29 and FaDu) or normal cell lines (HGF, HFF-1). Dose enhancement ratio at 50?% survival fraction (DERIC50) was calculated for samples pre-treated with NO(2)OA followed by gamma irradiation. NO(2)OA suppressed viability and induced apoptotic cell death. These effects were cell line specific but not in general selective for cancer cells. HT-29 cell line exerted higher sensitivity toward NO(2)OA treatment among cancer cell lines tested: induction of cell cycle arrest in the G2/M phase was associated with an increase in p21 and a decrease in cyclin D1 expression. Pre-treatment of HT-29 cells with NO(2)OA prior irradiation showed a significantly increased DERIC50, demonstrating radiosensitizing effects. In conclusion, NO(2)OA exhibited potential for combined chemoradiotherapy. Our results encourage the development of new NFAs with improved features for cancer chemoradiation.
    PracovištěBiofyzikální ústav
    KontaktJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Rok sběru2024
    Elektronická adresahttps://www.degruyter.com/document/doi/10.1515/hsz-2023-0150/html
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.