Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei

0583119 - BC 2024 RIV US eng A - Abstrakt
Kunzová, Michaela - Doleželová, Eva - Zíková, Alena
Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei.
European Journal of Clinical Investigation. Wiley. Roč. 53, č. 1 (2023), č. článku 57ASM – 161. ISSN 0014-2972. E-ISSN 1365-2362.
[57TH ANNUAL SCIENTIFIC MEETING-7-9 June 2023, Prague, Czech Republic. 07.06.2023-09.06.2023, Praha]
GRANT EU: European Commission(XE) 101044951 - MitoSignal
Institucionální podpora: RVO:60077344
Klíčová slova: bioenergetics * mitochondrial * Trypanosoma brucei
Obor OECD: Microbiology
https://onlinelibrary.wiley.com/doi/10.1111/eci.13992

Background: In the last decade, the importance of mitochondrially derived reactive oxygen species (OS) as signals in intracellular communication has been sealed. These though-to-be harmful molecules influence cellular faith decisions and can drive cells towards proliferation, apoptosis or differentiation. The OS are mainly generated as by-products during the process of oxidative phosphorylation (OXPHOS), which is completed by FoF1-ATP synthase with the formation of ATP. In trypanosomes, unicellular parasites undergoing programmed life cycle development, the cellular differentiation is linked to increased mitochondrial metabolic activity and OS production.
Trvalý link: https://hdl.handle.net/11104/0351112