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Solid-phase synthesis as a tool to create exactly defined, branched polymer vectors for cell membrane targeting
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SYSNO ASEP 0582834 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Solid-phase synthesis as a tool to create exactly defined, branched polymer vectors for cell membrane targeting Tvůrce(i) Elter, Johanna K. (UMCH-V) ORCID, SAI
Liščáková, Veronika (UOCHB-X) ORCID
Moravec, Oliver (UMCH-V)
Vragović, Martina (UMCH-V)
Filipová, Marcela (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Šácha, Pavel (UOCHB-X) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDZdroj.dok. Macromolecules. - : American Chemical Society - ISSN 0024-9297
Roč. 57, č. 3 (2024), s. 1050-1071Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova peptoids ; sequence-defined polymer ; solid-phase synthesis Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Vědní obor RIV – spolupráce Ústav organické chemie a biochemie - Ostatní lékařské obory CEP GA21-04166S GA ČR - Grantová agentura ČR LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy NU22-03-00318 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 ; UOCHB-X - RVO:61388963 UT WOS 001162121300001 EID SCOPUS 85184746879 DOI 10.1021/acs.macromol.3c02600 Anotace Modern drug formulations often require, besides the active drug molecule, auxiliaries to enhance their pharmacological properties. Tailor-made, biocompatible polymers covalently connected to the drug molecule can fulfill this function by increasing its solubility, reducing its toxicity, and guiding it to a specific target. If targeting membrane-bound proteins, localization of the drug close to the cell membrane and its target is beneficial to increase drug efficiency and residence time. In this study, we present the synthesis of highly defined, branched polymeric structures with membrane-binding properties. One to three hydrophilic poly(ethylene oxide) or poly(2-ethyloxazoline) side chains were connected via a peptoid backbone using a two-step iterative protocol for solid-phase peptoid synthesis. Additional groups, e.g., a hydrophobic anchor for membrane attachment, were introduced. Due to the nature of solid-phase synthesis, the number and order of the side chains and additional units can be precisely defined. The method proved to be versatile for the generation of multifunctional, branched polymeric structures of molecular weights up to approximately 7000 g mol–1. The behavior of all compounds towards biological membranes and cells was investigated using liposomes as cell membrane models, HEK293 and U251-MG cell lines, and red blood cells, thereby demonstrating their potential value as drug auxiliaries with cell membrane affinity. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.macromol.3c02600
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