Počet záznamů: 1
A novel bifunctional multilayered nanofibrous membrane combining polycaprolactone and poly (vinyl alcohol) enriched with platelet lysate for skin wound healing
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SYSNO ASEP 0582101 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A novel bifunctional multilayered nanofibrous membrane combining polycaprolactone and poly (vinyl alcohol) enriched with platelet lysate for skin wound healing Tvůrce(i) Blanquer, Andreu (FGU-C) RID, ORCID
Kuželová Košťáková, E. (CZ)
Filová, Elena (FGU-C) RID, ORCID
Lisnenko, M. (CZ)
Brož, Antonín (FGU-C) RID, ORCID, SAI
Müllerová, J. (CZ)
Novotný, V. (CZ)
Havlíčková, K. (CZ)
Jakubková, Š. (CZ)
Hauzerová, Š. (CZ)
Heczková, B. (CZ)
Procházková, R. (CZ)
Bačáková, Lucie (FGU-C) RID, ORCID
Jenčová, V. (CZ)Celkový počet autorů 14 Zdroj.dok. Nanoscale. - : Royal Society of Chemistry - ISSN 2040-3364
Roč. 16, č. 4 (2024), s. 1924-1941Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova electrospun scaffolds ; aliphatic polyesters ; rich plasma Obor OECD Biomaterials (as related to medical implants, devices, sensors) CEP LX22NPO5104 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EH22_008/0004562 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF18_046/0016045 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Výzkumná infrastruktura Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i. Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 001135685400001 EID SCOPUS 85182224707 DOI https://doi.org/10.1039/d3nr04705a Anotace Skin wound healing is a complex physiological process that involves various cell types, growth factors, cytokines, and other bioactive compounds. In this study, a novel dual-function multilayered nanofibrous membrane is developed for chronic wound application. The membrane is composed of five alternating layers of polycaprolactone (PCL) and poly (vinyl alcohol) (PVA) nanofibers (PCL-PVA) with a dual function: the PCL nanofibrous layers allow cell adhesion and growth, and the PVA layers enriched with incorporated platelet lysate (PCL-PVA + PL) serve as a drug delivery system for continuous release of bioactive compounds from PL into an aqueous environment. The material is produced using a needleless multi-jet electrospinning approach which can lead to homogeneous large-scale production. The bioactive PCL-PVA + PL membranes are cytocompatible and hemocompatible. A spatially compartmented co-culture of three cell types involved in wound healing keratinocytes, fibroblasts and endothelial cells is used for cytocompatibility studies. PCL-PVA + PL membranes enhance the proliferation of all cell types and increase the migration of both fibroblasts and endothelial cells. The membranes are also hemocompatible without any deleterious effect for thrombogenicity, hemolysis and coagulation. Thus, the beneficial effect of the PCL-PVA + PL membrane is demonstrated in vitro, making it a promising scaffold for the treatment of chronic wounds. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2025 Elektronická adresa https://doi.org/10.1039/D3NR04705A
Počet záznamů: 1