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Radium targets for cyclotron production of .sup.225./sup.Ac in view of targeted alpha therapy
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SYSNO ASEP 0579004 Druh ASEP A - Abstrakt Zařazení RIV O - Ostatní Název Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy Tvůrce(i) Kellerbauer, A. (DE)
Malmbeck, R. (DE)
Carrpico De Almeida, C. (DE)
Jajcisinova, E. (BE)
Eloirdi, R. (DE)
Lebeda, Ondřej (UJF-V) RID, ORCID, SAI
Morgenstern, A. (DE)Celkový počet autorů 7 Zdroj.dok. European Journal of Nuclear Medicine and Molecular Imaging. - : Springer - ISSN 1619-7070
Roč. 50, Supplement 1 (2023), S11-S11Poč.str. 1 s. Forma vydání Tištěná - P Akce Annual Congress of the European Association of Nuclear Medicine (ENAM'23) Datum konání 09.09.2023 - 13.09.2023 Místo konání Vienna Země AT - Rakousko Typ akce WRD Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Ac-225 production ; radiology imaging ; alpha therapy Obor OECD Radiology, nuclear medicine and medical imaging Institucionální podpora UJF-V - RVO:61389005 UT WOS 001084059700010 DOI 10.1007/s00259-023-06333-x Anotace Targeted alpha therapy using the radionuclide Ac-225 has shown remarkable beneft in clinical trials to patients sufering from various cancer types. Currently most Ac-225 is produced from a few sources of Th-229 existing worldwide. However, the total amount available is only sufcient for a few thousand patient doses. Given a projected demand that is several orders of magnitude higher, alternative paths for the production of Ac-225 must be developed. We have been investigating the route
using the Ra-226(p,2n)Ac-225 reaction. It is particularly attractive due to its large cross-section near 17 MeV proton energy and because it can be readily employed at a large number of cyclotron facilities. The excitation function of this reaction has been previously measured by us for a few energies, but discrepancies with calculations remain. Hence, new irradiation experiments are required to improve the knowledge of the excitation function to support the industrial production of Ac-225 via this route.Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2024 Elektronická adresa https://doi.org/10.1007/s00259-023-06333-x
Počet záznamů: 1