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In Vitro and In Silico Studies of Functionalized Polyurethane Surfaces toward Understanding Biologically Relevant Interactions
- 1.0578939 - ÚFCH JH 2024 RIV US eng J - Článek v odborném periodiku
Chytrosz-Wrobel, P. - Golda-Cepa, M. - Drozdz, K. - Rysz, J. - Kubisiak, P. - Kulig, W. - Brzychczy-Wloch, M. - Cwiklik, Lukasz - Kotarba, A.
In Vitro and In Silico Studies of Functionalized Polyurethane Surfaces toward Understanding Biologically Relevant Interactions.
ACS Biomaterials Science & Engineering. Roč. 9, č. 11 (2023), s. 6112-6122. ISSN 2373-9878. E-ISSN 2373-9878
Grant CEP: GA ČR GF22-27317K
Institucionální podpora: RVO:61388955
Klíčová slova: nitrogen plasma treatment * biomedical applications * biomaterials * crystallinity * polymers * protein * chain * polyurethane * oxygen plasma * biocompatibility * bacteria adhesion * moleculardynamics
Obor OECD: Physical chemistry
Impakt faktor: 5.4, rok: 2023
Způsob publikování: Open access
The solid-aqueous boundary formed upon biomaterial implantation provides a playground for most biochemical reactions and physiological processes involved in implant-host interactions. Therefore, for biomaterial development, optimization, and application, it is essential to understand the biomaterial-water interface in depth. In this study, oxygen plasma-functionalized polyurethane surfaces that can be successfully utilized in contact with the tissue of the respiratory system were prepared and investigated. Through experiments, the influence of plasma treatment on the physicochemical properties of polyurethane was investigated by atomic force microscopy, attenuated total reflection infrared spectroscopy, differential thermal analysis, X-ray photoelectron spectroscopy, secondary ion mass spectrometry, and contact angle measurements, supplemented with biological tests using the A549 cell line and two bacteria strains (Staphylococcus aureus and Pseudomonas aeruginosa). The molecular interpretation of the experimental findings was achieved by molecular dynamics simulations employing newly developed, fully atomistic models of unmodified and plasma-functionalized polyurethane materials to characterize the polyurethane-water interfaces at the nanoscale in detail. The experimentally obtained polar and dispersive surface free energies were consistent with the calculated free energies, verifying the adequacy of the developed models. A 20% substitution of the polymeric chain termini by their oxidized variants was observed in the experimentally obtained plasma-modified polyurethane surface, indicating the surface saturation with oxygen-containing functional groups.
Trvalý link: https://hdl.handle.net/11104/0347848
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