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Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lactic-co-glycolic acid)
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SYSNO ASEP 0575630 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lactic-co-glycolic acid) Tvůrce(i) Dodda, J. M. (CZ)
Azar, M. G. (CZ)
Bělský, P. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Gajdošová, Veronika (UMCH-V) RID, ORCID
Kasi, P. B. (CZ)
Anerillas, L. O. (SE)
Kovářík, T. (CZ)Číslo článku 126654 Zdroj.dok. International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 248, 1 September (2023)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova resorbable blends ; polycaprolactone ; nanoscale morphology Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001079905600001 EID SCOPUS 85170288716 DOI 10.1016/j.ijbiomac.2023.126654 Anotace Recent complications on the use of polypropylene meshes for hernia repair has led to the development of meshes or films, which were based on resorbable polymers such as polycaprolactone (PCL), polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These materials are able to create suitable bioactive environment for the growth and development of cells. In this research, we mainly focused on the relations among structure, mechanical performance and biocompatiblity of PCL/PLA and PCL/PLGA and blends prepared by solution casting. The films were characterized regarding the chemical structure, morphology, physicochemical properties, cytotoxicity, biocompatibility and cell growth. All the films showed high tensile strength ranging from 9.5 to 11.8 MPa. SAXS showed that the lamellar stack structure typical for PCL was present even in the blend films while the morphological parameters of the stacks varied slightly with the content of PLGA or PLA in the blends. WAXS indicated preferential orientation of crystallites (and thus, also the lamellar stacks) in the blend films. In vitro studies revealed that PCL/PLGA films displayed better cell adhesion, spreading and proliferation than PCL/PLA and PCL films. Further the effect of blending on the degradation was investigated, to understand the significant variable within the process that could provide further control of cell adhesion. The results showed that the investigated blend films are promising materials for biomedical applications. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0141813023035511?via%3Dihub
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