Počet záznamů: 1
Which Moiety Drives Gangliosides to Form Nanodomains?
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SYSNO ASEP 0573011 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Which Moiety Drives Gangliosides to Form Nanodomains? Tvůrce(i) Davidović, David (UFCH-W) SAI
Kukulka, M. (PL)
Sarmento, M. J. (PT)
Mikhalyov, I. (RU)
Gretskaya, N. (RU)
Chmelová, Barbora (UFCH-W)
Ricardo, Joana Catarina (UFCH-W) ORCID, SAI, RID
Hof, Martin (UFCH-W) RID, ORCID
Cwiklik, Lukasz (UFCH-W) RID, ORCID
Šachl, Radek (UFCH-W) RID, ORCIDZdroj.dok. Journal of Physical Chemistry Letters. - : American Chemical Society - ISSN 1948-7185
Roč. 14, č. 25 (2023), s. 5791-5797Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Lipid nanodomains ; membrane organization ; chain base composition Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GC20-01401J GA ČR - Grantová agentura ČR Výzkumná infrastruktura e-INFRA CZ - 90140 - CESNET, zájmové sdružení právnických osob Způsob publikování Open access Institucionální podpora UFCH-W - RVO:61388955 UT WOS 001011480300001 EID SCOPUS 85164060948 DOI 10.1021/acs.jpclett.3c00761 Anotace Gangliosides are important glycosphingolipids involved in a multitude of physiological functions. From a physicochemical standpoint, this is related to their ability to self-organize into nanoscopic domains, even at molar concentrations of one per 1000 lipid molecules. Despite recent experimental and theoretical efforts suggesting that a hydrogen bonding network is crucial for nanodomain stability, the specific ganglioside moiety decisive for the development of these nanodomains has not yet been identified. Here, we combine an experimental technique achieving nanometer resolution (Förster resonance energy transfer analyzed by Monte Carlo simulations) with atomistic molecular dynamic simulations to demonstrate that the sialic acid (Sia) residue(s) at the oligosaccharide headgroup dominates the hydrogen bonding network between gangliosides, driving the formation of nanodomains even in the absence of cholesterol or sphingomyelin. Consequently, the clustering pattern of asialoGM1, a Sia-depleted glycosphingolipid bearing three glyco moieties, is more similar to that of structurally distant sphingomyelin than that of the closely related gangliosides GM1 and GD1a with one and two Sia groups, respectively. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2024 Elektronická adresa https://hdl.handle.net/11104/0343536
Počet záznamů: 1