Počet záznamů: 1
Ancient and pervasive expansion of adaptin-related vesicle coat machinery across Parabasalia
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SYSNO ASEP 0572375 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Ancient and pervasive expansion of adaptin-related vesicle coat machinery across Parabasalia Tvůrce(i) Maciejowski, W.J. (CA)
Gile, G.H. (CA)
Jerlstrom-Hultqvist, J. (CA)
Dacks, Joel Bryan (BC-A) SAI, ORCIDCelkový počet autorů 4 Zdroj.dok. International Journal for Parasitology. - : Elsevier - ISSN 0020-7519
Roč. 53, č. 4 (2023), s. 233-245Poč.str. 13 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Membrane trafficking ; Trichomonas vaginalis ; Evolutionary cell biology ; Clathrin ; copi ; Metamonada Vědní obor RIV EA - Morfologické obory a cytologie Obor OECD Cell biology Způsob publikování Omezený přístup Institucionální podpora BC-A - RVO:60077344 UT WOS 000981660300001 EID SCOPUS 85151465890 DOI 10.1016/j.ijpara.2023.01.002 Anotace The eukaryotic phylum Parabasalia is composed primarily of anaerobic, endobiotic organisms such as the veterinary parasite Tritrichomonas foetus and the human parasite Trichomonas vaginalis, the latter causing the most prevalent, non-viral, sexually transmitted disease world-wide. Although a parasitic lifestyle is generally associated with a reduction in cell biology, T. vaginalis provides a striking counter-example. The 2007 T. vaginalis genome paper reported a massive and selective expansion of encoded proteins involved in vesicle trafficking, particularly those implicated in the late secretory and endocytic systems. Chief amongst these were the hetero-tetrameric adaptor proteins or 'adaptins', with T. vaginalis encoding3.5 times more such proteins than do humans. The provenance of such a complement, and how it relates to the transition from a free-living or endobiotic state to parasitism, remains unclear. In this study, we performed a comprehensive bioinformatic and molecular evolutionary investigation of the heterotetrameric cargo adaptor-derived coats, comparing the molecular complement and evolution of these proteins between T. vaginalis, T. foetus and the available diversity of endobiotic parabasalids. Notably, with the recent discovery of Anaeramoeba spp. as the free-living sister lineage to all parabasalids, we were able to delve back to time points earlier in the lineage's history than ever before. We found that, although T. vaginalis still encodes the most HTAC subunits amongst parabasalids, the duplications giving rise to the complement took place more deeply and at various stages across the lineage. While some duplications appear to have convergently shaped the parasitic lineages, the largest jump is in the transition from free-living to endobiotic lifestyle with both gains and losses shaping the encoded complement. This work details the evolution of a cellular system across an important lineage of parasites and provides insight into the evolutionary dynamics of an example of expansion of protein machinery, counter to the more common trends observed in many parasitic systems.(c) 2023 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0020751923000462?via%3Dihub
Počet záznamů: 1