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Phosphorus-containing polymers as sensitive biocompatible probes for 31P magnetic resonance
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SYSNO ASEP 0569669 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Phosphorus-containing polymers as sensitive biocompatible probes for 31P magnetic resonance Tvůrce(i) Kracíková, Lucie (UMCH-V) ORCID
Androvič, Ladislav (UMCH-V) ORCID
Potočková, Iveta (UMCH-V)
Ziolkowska, N. (CZ)
Vít, M. (CZ)
Červený, D. (CZ)
Jirák, D. (CZ)
Laga, Richard (UMCH-V) RID, ORCIDČíslo článku 2334 Zdroj.dok. Molecules. - : MDPI
Roč. 28, č. 5 (2023)Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova phosphorus-containing polymers ; controlled polymerization ; polymer probes Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP NU20-08-00095 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000948203900001 EID SCOPUS 85150206100 DOI 10.3390/molecules28052334 Anotace The visualization of organs and tissues using 31P magnetic resonance (MR) imaging represents an immense challenge. This is largely due to the lack of sensitive biocompatible probes required to deliver a high-intensity MR signal that can be distinguished from the natural biological background. Synthetic water-soluble phosphorus-containing polymers appear to be suitable materials for this purpose due to their adjustable chain architecture, low toxicity, and favorable pharmacokinetics. In this work, we carried out a controlled synthesis, and compared the MR properties, of several probes consisting of highly hydrophilic phosphopolymers differing in composition, structure, and molecular weight. Based on our phantom experiments, all probes with a molecular weight of ~3–400 kg·mol−1, including linear polymers based on poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), poly(ethyl ethylenephosphate) (PEEP), and poly[bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)]phosphazene (PMEEEP) as well as star-shaped copolymers composed of PMPC arms grafted onto poly(amidoamine) dendrimer (PAMAM-g-PMPC) or cyclotriphosphazene-derived cores (CTP-g-PMPC), were readily detected using a 4.7 T MR scanner. The highest signal-to-noise ratio was achieved by the linear polymers PMPC (210) and PMEEEP (62) followed by the star polymers CTP-g-PMPC (56) and PAMAM-g-PMPC (44). The 31P T1 and T2 relaxation times for these phosphopolymers were also favorable, ranging between 1078 and 2368 and 30 and 171 ms, respectively. We contend that select phosphopolymers are suitable for use as sensitive 31P MR probes for biomedical applications.
Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/1420-3049/28/5/2334
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