Počet záznamů: 1
Release of HMGB1 and Toll-like Receptors 2, 4, and 9 Signaling Are Modulated by Bifidobacterium animalis subsp. lactis BB-12 and Salmonella Typhimurium in a Gnotobiotic Piglet Model of Preterm Infants
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SYSNO ASEP 0569333 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Release of HMGB1 and Toll-like Receptors 2, 4, and 9 Signaling Are Modulated by Bifidobacterium animalis subsp. lactis BB-12 and Salmonella Typhimurium in a Gnotobiotic Piglet Model of Preterm Infants Tvůrce(i) Šplíchal, Igor (MBU-M) RID
Donovan, S. M. (US)
Kindlová, Zdislava (MBU-M)
Straňák, Z. (CZ)
Neužil Bunešová, V. (CZ)
Šinkora, Marek (MBU-M) RID, ORCID
Poláková, Kateřina (MBU-M)
Valášková, Barbora (MBU-M)
Šplíchalová, Alla (MBU-M) RID, ORCIDČíslo článku 2329 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 24, č. 3 (2023)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Bifidobacterium animalis subsp ; lactis BB-12 ; Salmonella Typhimurium ; high mobility group box 1 ; Toll-like receptors ; tight junction proteins ; mucin ; intestinal barrier ; inflammatory cytokines ; immunodeficient host Obor OECD Biochemistry and molecular biology CEP GA13-14736S GA ČR - Grantová agentura ČR GA20-03282S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000930754400001 EID SCOPUS 85147926162 DOI 10.3390/ijms24032329 Anotace Gnotobiotic (GN) animals with defined microbiota allow us to study host-microbiota and microbiota-microbiota interferences. Preterm germ-free (GF) piglets were mono-associated with probiotic Bifidobacterium animalis subsp. lactis BB-12 (BB12) to ameliorate/prevent the consequences of infection with the Salmonella Typhimurium strain LT2 (LT2). Goblet cell density, expression of Toll-like receptors (TLRs) 2, 4, and 9, high mobility group box 1 (HMGB1), interleukin (IL)-6, and IL-12/23p40 were analyzed to evaluate the possible modulatory effect of BB12. BB12 prevented an LT2-induced decrease of goblet cell density in the colon. TLRs signaling modified by LT2 was not influenced by the previous association with BB12. The expression of HMGB1, IL-6, and IL12/23p40 in the jejunum, ileum, and colon and their levels in plasma were all decreased by BB12, but these changes were not statistically significant. In the colon, differences in HMGB1 distribution between the GF and LT2 piglet groups were observed. In conclusion, the mono-association of GF piglets with BB12 prior to LT2 infection partially ameliorated the inflammatory response to LT2 infection. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/1422-0067/24/3/2329
Počet záznamů: 1