Počet záznamů: 1
Advanced Tool for Chiral Separations of Anionic and Zwitterionic (Metalla)carboranes: Supercritical Fluid Chromatography
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SYSNO ASEP 0566035 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Advanced Tool for Chiral Separations of Anionic and Zwitterionic (Metalla)carboranes: Supercritical Fluid Chromatography Tvůrce(i) Horáček, O. (CZ)
Nováková, L. (CZ)
Tüzün, Ece Zeynep (UACH-T) ORCID, RID, SAI
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Švec, F. (CZ)
Kučera, R. (CZ)Celkový počet autorů 6 Zdroj.dok. Analytical Chemistry. - : American Chemical Society - ISSN 0003-2700
Roč. 94, č. 50 (2022), s. 17551-17558Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Anions ; Cobalt ; Mixtures ; Reaction products ; Selectivity Vědní obor RIV CA - Anorganická chemie Obor OECD Inorganic and nuclear chemistry CEP GA21-14409S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UACH-T - RVO:61388980 UT WOS 000893797700001 EID SCOPUS 85143878207 DOI 10.1021/acs.analchem.2c03895 Anotace The continuous expansion of research in the field of stable carboranes and their wide potential in the drug design require carrying out fundamental studies regarding their chiral separations. Although supercritical fluid chromatography (SFC) is a viable technique for fast enantioseparations, no investigation concerning boron cluster compounds has been done yet. We aimed at the development of a straightforward method enabling chiral separations of racemic mixtures of anionic cluster carboranes and metallacarboranes that represent an analytical challenge. The fast gradient screening testing nine polysaccharide-based columns was used. The key parameters affecting the selectivity were the type of chiral selector, the type of alcohol, and the base in cosolvent. Moreover, the addition of acetonitrile or water to the cosolvent was identified as an effective tool for decreasing the analysis time while preserving the resolution. After the optimization, the chiral separations of 19 out of 20 selected compounds were achieved in less than 10 min. These results demonstrate the clear advantage of SFC over chiral separations using HPLC in terms of both analysis time and structural variety of successfully separated compounds. Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2023 Elektronická adresa https://doi.org/10.1021/acs.analchem.2c03895
Počet záznamů: 1