Healthy Microbiome – A Mere Idea or a Sound Concept?

0565865 - MBÚ 2023 RIV CZ eng J - Článek v odborném periodiku
Najmanová, Lucie - Vídeňská, P. - Cahová, M.
Healthy Microbiome – A Mere Idea or a Sound Concept?
Physiological Research. Roč. 71, NOV 25 (2022), s. 719-738. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NV18-01-00040
Institucionální podpora: RVO:61388971
Klíčová slova: Holobiont * Core microbiome function * Resilience * Microbiome ecology * One health hypothesis * Dysbiosis
Obor OECD: Microbiology
Impakt faktor: 2.1, rok: 2022
Způsob publikování: Open access
https://www.biomed.cas.cz/physiolres/pdf/2022/71_719.pdf

Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: “What is the healthy microbiome?” or “Is it possible to define it unequivocally?”. In this review, we describe the main hindrances complicating the definition of “healthy microbiome” in terms of microbiota composition. We discuss the human microbiome from the perspective of classical ecology and we advocate for the shift from the stress on microbiota composition to the functions that microbiome ensures for the host. Finally, we propose to leave the
concept of ideal healthy microbiome and replace it by focus on microbiome advantageous for the host, which always depends on
the specific context like the age, genetics, dietary habits, body
site or physiological state


Trvalý link: https://hdl.handle.net/11104/0337358