Počet záznamů: 1
Bioactive Natural Products
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SYSNO ASEP 0564409 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Biosynthesis of polyunsaturated fatty acids by metabolic engineering of yeast Yarrowia lipolytica Tvůrce(i) Palyzová, Andrea (MBU-M) RID, ORCID
Spížek, Jaroslav (MBU-M)
Vítová, Milada (MBU-M) RID, ORCID
Řezanka, Tomáš (MBU-M) ORCIDZdroj.dok. Bioactive Natural Products, Studies in Natural Products Chemistry. - Amsterdam : Elsevier B.V., 2022 / Atta-ur-Rahman - ISBN 978-0-323-91099-6 Rozsah stran s. 197-223 Poč.str. 27 s. Poč.str.knihy 481 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Yeast ; Yarrowia lipolytica ; Polyunsaturated fatty acids ; Genetically modified ; biosynthesis Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Institucionální podpora MBU-M - RVO:61388971 Anotace Metabolic engineering describes the involvement of primary metabolism in the overproduction of native and atypical metabolites, including nutraceuticals—compounds of great interest due to their health-promoting or disease-preventing properties—thus overcoming limitations of traditional low-yield extractions of natural materials or of complex chemical syntheses.
Omega-3 fatty acids, all cis-5,8,11,14,17-eicosapentaenoic (C20:5, EPA), and all-cis-4,7,10,13,16,19-docosahexaenoic (C22:6, DHA) acids provide great benefits in improving human health in adults and developing infants. Currently, the main source of EPA and DHA is fish oil, and microalgae are also used as a secondary source of DHA. However, because of the high demand for EPA and DHA, many synthetic methods have been developed for producing these and other ω-3 fatty acids, including metabolically engineered strains of oleaginous yeasts, especially Yarrowia lipolytica. This review describes current metabolic engineering strategies used in the manufacture of some nutraceuticals, especially high levels of polyunsaturated fatty acids (PUFAs).Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/abs/pii/B9780323910996000074
Počet záznamů: 1