Počet záznamů: 1
Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm
- 1.0562057 - ÚEB 2023 RIV GB eng J - Článek v odborném periodiku
Yang, M. - Özdemir, Zülal - Kim, H. - Nah, S. - Andris, Erik - Li, X. - Wimmer, Zdeněk - Yoon, J.-N.
Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm.
Advanced Healthcare Materials. Roč. 11, č. 14 (2022), č. článku 2200529. ISSN 2192-2640. E-ISSN 2192-2659
Grant CEP: GA MPO(CZ) FV10599; GA MŠMT(CZ) EF16_019/0000729
Grant ostatní: AVČR(CZ) VAJVA-19-48
Výzkumná infrastruktura: e-INFRA CZ - 90140
Institucionální podpora: RVO:61389030 ; RVO:61388963
Klíčová slova: acid-responsive nanoporphyrin * MRSA biofilms * NIR fluorescence * phototherapy * structural evolution
Obor OECD: Organic chemistry
Impakt faktor: 10, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1002/adhm.202200529
Combating biofilm infections remains a challenge due to the shield and acidic conditions. Herein, an acid-responsive nanoporphyrin (PN3-NP) based on the self-assembly of a water-soluble porphyrin derivative (PN3) is constructed. Additional kinetic control sites formed by the conjugation of the spermine molecules to a porphyrin macrocycle make PN3 self-assemble into stable nanoparticles (PN3-NP) in the physiological environment. Noteworthily, near-infrared (NIR) fluorescence monitoring and synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) effects of PN3-NP can be triggered by the acidity in biofilms, accompanied by intelligent transformation into dot-like nanospheres. Thus, damage to normal tissue is effectively avoided and accurate diagnosis and treatment of biofilms is achieved successfully. The good results of fluorescence imaging-guided photo-ablation of antibiotic-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) biofilms verify that PN3-NP is a promising alternative to antibiotics. Meanwhile, this strategy also opens new horizons to engineer smart nano-photosensitizer for accurate diagnosis and treatment of biofilms.
Trvalý link: https://hdl.handle.net/11104/0334475
Název souboru Staženo Velikost Komentář Verze Přístup 2022_Yang_ADVANCED HEALTHCARE MATERIALS_2200529.pdf 3 3.4 MB Jiná vyžádat
Počet záznamů: 1