Počet záznamů: 1
Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production
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SYSNO ASEP 0555981 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production Tvůrce(i) Vokurka, M. (CZ)
Lacina, L. (CZ)
Brabek, J. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Ng, Y.Z. (SG)
Smetana Jr, K. (CZ)Celkový počet autorů 6 Číslo článku 964 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 23, č. 2 (2022)Poč.str. 22 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cancer microenvironment ; cancer ecosystem ; cancer-associated fibroblast ; il-6 ; exosome Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP EF16_019/0000785 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA19-05048S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 000748216800001 DOI 10.3390/ijms23020964 Anotace Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/1422-0067/23/2/964
Počet záznamů: 1